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PLASMA MEMBRANES IN ACUTE LIVER INJURY. BIOCHEMICAL CHANGES INDUCED BY CARBON TETRACHLORIDE
Author(s) -
Le Page RN,
Dorling PR
Publication year - 1971
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1971.36
Subject(s) - carbon tetrachloride , hepatotoxin , membrane , enzyme , chemistry , atpase , carbon tetrachloride poisoning , biochemistry , liver injury , plasma , medicine , pharmacology , toxicity , biology , organic chemistry , physics , quantum mechanics
Summary Plasma membranes isolated from liver of rats given a single high dose of carbon tetrachloride were compared with controls, with respect to activity of three enzymes, 5′‐mononucleotidase, Na + ‐K + ‐ATPase and Mg 2+ ‐ATPase. All three enzymes showed decreases in activity in the period 2½‐18 h following dosing with CCl 4 . This is considered as direct evidence that biochemical changes arise in the liver‐cell plasma membrane at an early stage after poisoning of rats with this hepatotoxin.