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A METHOD FOR MEASURING THE NORMAL BLOOD VOLUME OF THE RAT USING [ 125 I]LABELLED ALBUMIN
Author(s) -
Brooks Sandra
Publication year - 1971
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1971.23
Subject(s) - volume (thermodynamics) , albumin , blood volume , standard deviation , normal values , blood volume determination , body weight , nuclear medicine , chemistry , chromatography , mathematics , medicine , statistics , physics , biochemistry , thermodynamics
Summary A reliable method of estimating blood volume in the rat using [ 125 I]labelled albumin is described. In 16 normal animals the blood volume was found to be 5·59 ml./100 g. body weight (± 0·44 ml. standard deviation). A standard error of ± 0·11 ml. in this technique is small and therefore should allow changes in blood volume due to pathological states to be accurately measured.