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ANOMALOUS BEHAVIOUR OF BLOOD VOLUME FOLLOWING ACUTE SEVERE HAEMORRHAGE
Author(s) -
Furneaux RW,
Tracy GD
Publication year - 1970
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1970.62
Subject(s) - blood volume , medicine , venous blood , venous return curve , arterial blood , anesthesia , volume (thermodynamics) , cardiology , hemodynamics , physics , quantum mechanics
Summary Anaesthetized dogs, which had undergone previous splenectomy, were subjected to mild (10% blood volume), moderate (30% blood volume) and severe (46% blood volume) haemorrhage. The arterial and central venous pressures, blood volume and haematocrit were measured before and after haemorrhage. In the mild and moderately bled dogs there was a return of all observed parameters to their control, prebleed values. All of these animals survived the duration of the experiment. In the severely bled animals there was a negligible return of both arterial and central venous pressures, an absence of blood volume repletion and no significant changes in large vessel haematocrit. All of these animals died. It is suggested that these observations might result from a gross reduction in the area of the vascular bed being perfused following severe haemorrhage.