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THE IMMUNOLOGICAL STATUS OF THE BONE MARROW CELLS OF SHEEP ERYTHROCYTE‐TOLERANT RATS
Author(s) -
McCullagh PJ
Publication year - 1970
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1970.53
Subject(s) - bone marrow , thoracic duct , spleen , immune system , lymph , biology , pathology , immunology , lymphatic system , medicine
Summary No evidence could be obtained for specific collaboration between cells derived from thymus and bone marrow in the immune response of rats to sheep erythrocytes. Bone marrow cells did not enhance the ability of thoracic duct lymphocytes to restore immune responsiveness to sheep erythrocytes in irradiated rats. In comparison with thoracic duct lymphocytes, thymus cells were most inefficient as an immunologically restorative inoculum in this situation, and done marrow cells did not augment their performance. Bone marrow cells augmented the restorative capacity of spleen cells from immunized, irradiated donors, regardless of whether these had been injected previously with thymus or bone marrow cells. No evidence was forthcoming for the existence of a modified subpopulation of cells in the thoracic duct lymph of tolerant rats.