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THE RESPONSE OF MICE TO THE INTRAVENOUS INJECTION OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS
Author(s) -
Tosolini FA
Publication year - 1970
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1970.46
Subject(s) - lymphocytic choriomeningitis , virus , biology , central nervous system , pathology , virology , infiltration (hvac) , cerebrospinal fluid , antibody , arenavirus , immunology , medicine , immune system , cd8 , physics , neuroscience , thermodynamics
Summary The initiation and development of infection in the visceral organs and the central nervous system of mice after intravenous injection of the WE 3 strain of lymphoctytic choriomeningitis virus has been studied by the immunofluorescence technique and correlated with histological changes. In the liver, virus was taken up within a few minutes by Kupffer cells. Viral replication first occurred within these cells and infection spread from them to hepatic cells. Infiltration of the tissues by mononuclear cells, necrotic changes and signs of sickness all developed at about the same time. Necrosis occurred in foci of infected cells and immunoglobulin was present in and around the lesions. In the central nervous system, lymphocytic choriomeningitis virus infected the walls of blood vessels and passed through the meringue vessels into the surrounding tissue and into the cerebrospinal fluid. Spread of infection from the choroids plexuses occurred at a later stage, but infection was not transmitted from cerebral blood vessels to cells in the brain substance. In infant mice inoculated extraneurally with lymphocytes the choriomeningitis virus, invasion of the central nervous system occurred much earlier and more readily than in adult mice and there was widespread infection of the brain substance as well as the meanings.