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STUDIES ON CYTOPHILIC ANTIBODIES
Author(s) -
Nelson DS
Publication year - 1970
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1970.35
Subject(s) - antibody , immunization , immunology , globulin , trypsin , biology , freund's adjuvant , gamma globulin , chemistry , biochemistry , enzyme
Summary Serum obtained seven days after immunization of Swiss mice with sheep erythrocytes in Freund's adjuvant contains a factor, with fast α 1 ‐globulin mobility, detectable by its ability to induce the attachment of sheep erythrocytes to normal mouse macophages. The receptor on macrophages is trypsin‐sensitive. The factor has a large degree of, though not complete, immunological specificity. It appears to be unrelated to conventional immunoglobulins. non‐agglutinating and non‐complement‐fixing. Subsidiary evidence consistent with the existence of an α‐globulin “antibody” and a consideration of its possible immunological significance are presented.