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EFFECTS OF THE PROTEIN CONTENT OF THE DIET ON THE DEVELOPMENT OF NEPHROCALCINOSIS IN RATS
Author(s) -
Goulding Ailsa,
Malthus RS
Publication year - 1970
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1970.33
Subject(s) - nephrocalcinosis , chemistry , weanling , casein , calcium , cystine , medicine , amino acid , phosphate , endocrinology , urine , urea , methionine , phosphorus , biochemistry , kidney , biology , enzyme , organic chemistry , cysteine
Summary Nephrocalcinosis in weanling rats resulting from the feeding of a semi‐purified diet was found to be reduced by the addition of casein, gluten, amino acids (methionine, cystine and glutamic acid), or ammonium sulphate to the diet. The altered incidence of nephrocalcinosis did not appear to be related to the casein: salt mixture ratio, to changes in the serum calcium and phosphorus concentrations, or to changes in the volume of urine excreted. It is postulated that the protein supplements had an acidifying action due to oxidation of S‐amino acids which led to an increased urinary excretion of hydrogen ions and sulphate, and that the acidification of the tubular fluid increased the solubility of calcium phosphate so that less mineral deposition took place.