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FURTHER STUDIES ON A SKIN CALCIFYING SYSTEM
Author(s) -
Smillie AC,
Cousins FB
Publication year - 1970
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1970.14
Subject(s) - phosphate , calcification , apatite , pyrophosphate , phosphorus , chemistry , inorganic phosphate , fraction (chemistry) , deposition (geology) , environmental chemistry , mineralogy , biochemistry , medicine , biology , chromatography , organic chemistry , enzyme , paleontology , sediment
Summary The changes in distribution of phosphorus involved in initiating deposition of hydroxy apatite in an experimental system based on mineralisation of rat skin have been studied. Measurement of several major phosphate fractions indicated considerable movement of phosphorus, particularly between the inorganic and organic phosphate pools of the skin. There was also an uptake of phosporus by a collagen‐rich fraction, which was related both temporally and sequentially to mineralisation. The phosphate taken up was released from the collagen fraction within a few hours if calcification did not occur. Attempts to demonstrate an inhibitory role for pyrophosphate in this calcifying system were unsuccessful.