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THE EXCRETION OF VASOPRESSIN BY NORMAL AND DEHYDRATED SHEEP
Author(s) -
Yesberg Nancy E,
Henderson Myrna,
BudtzOlsen OE
Publication year - 1970
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1970.11
Subject(s) - vasopressin , reabsorption , excretion , dehydration , urine osmolality , medicine , free water clearance , endocrinology , chemistry , urine flow rate , urine , urea , renal physiology , potassium , sodium , renal function , kidney , biology , biochemistry , organic chemistry
Summary Urinary vasopressin excretion rates in normal sheep have been shown to range from less than 1 μU/minute to 138 μU/minute. They were inversely related to urine flow rate and directly related to urine osmolality. Dehydration led to an increase in vasopressin excretion up to a rate of 869 μU/minute which was associated with a decrease in urine flow rate and an increase in osmolality. Electrolyte excretion was not significantly related to vasopressin excretion rate in either the normal or dehydrated group, but both sodium and potassium output remained consistently low during dehydration. Evidence is presented that increased vasopressin allows the reabsorption of more solute‐free water for a given osmolar clearance, and that where dehydration results in a reduction of solute‐free water reabsorption it is due to a reduction in osmolar clearance, probably due to a vasopressin enhanced urea reabsorption.