Premium
RESPONSE OF THE PYLORIC AND PYLORIC‐OESOPHAGEAL LIGATED RAT TO INSULIN AND 2 DEOXY‐D‐GLUCOSE
Author(s) -
Hansky J,
Soveny Claire
Publication year - 1969
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1969.41
Subject(s) - pylorus , medicine , ligation , vagotomy , gastric acid , endocrinology , secretion , stimulation , insulin , stomach , chemistry , biology
Summary Acid secretion of pyloric and pyloric and oesophageal ligated rats has been assessed in response to graded doses of insulin and 2 Deoxy‐D‐glucose and tovagotomy. Neither insulin nor 2 Deoxy‐D‐glucose stimulated acid secretion in the pyloric ligated rat to a significant level above control values, but the pyloric and oesophageal ligated rat responded well to these stimulants. vagotomy markedly decreased acid secretion in the pyloric ligated rat, whereas the pyloric and oesophageal ligated rat showed a slight increase in acid output following vagotomy. These results suggest that vagal stimulation is the probable reason for the increase in gastric acid secretion produced by ligation of the pylorus in the rat and that reflex vagal inhibition may be the reason for the decreased acid production in this preparation by concomitant oesophageal ligation. They further illustrate the usefulness of the pyloric and oesophageal ligated rat as an assay medium for gastric stimulatory substances.