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TRANSFERRIN AND ALBUMIN DISTRIBUTION AND TURNOVER IN THE RABBIT
Author(s) -
Morgan EH
Publication year - 1969
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1969.39
Subject(s) - transferrin , albumin , distribution (mathematics) , chemistry , erythropoiesis , serum albumin , endocrinology , medicine , biochemistry , biology , anemia , mathematical analysis , mathematics
Summary The distribution and turnover of rabbit transferrin and albumin were measured simultaneously in rabbits using 131 I‐ and 125 I‐labelled purified transferrin and albumin. The plasma volumes determined with either protein were almost identical in 8 normal rabbits and in 4 with haemorrhagic anaemia and increased erythropoiesis. Similarly, the rates of transcapillary passage and relative distribution of the two proteins between intravascular and extravascular spaces were very similar. The fractional turnover rate of transferrin was approximately twice us great as that of albumin, but the absolute turnover of albumin was about 10 times as great as that of transferrin It is concluded that the amount of transferrin bound at cell surfaces in the rabbit is only a very small fraction of the total body transferrin, too small to be measured by the methods used.