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THE TRANSPORT OF CHOLESTEROL IN THORACIC DUCT LYMPH OF ANIMALS FED CHOLESTEROL WITH VARYING TRIGLYCERIDE LOADS
Author(s) -
Fraser R,
Courtice FC
Publication year - 1969
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1969.169
Subject(s) - chylomicron , cholesterol , lymph , triglyceride , medicine , endocrinology , chemistry , dietary cholesterol , lipoprotein , biology , very low density lipoprotein , pathology
Summary The sizes of cholesterol‐containing lipid particles were, on the whole, larger in thoracic duct lymph of rabbits and rats fed a cholesterol‐high fat diet than when fed a cholesterol‐low fat diet. The mean diameter of chylomicrons of S f > 400 from rabbits fed a diet containing 0.8% cholesterol‐30% corn oil was 1476 Å, while that from rabbits fed 0.8% cholesterol in plain food was 1065 Å. The mean diameters of the lipoproteins of Sf 12–400 were 493 and 499 Å respectively. Not only were chylomicrons larger in the cholesterol‐high fat diet group of rabbits, but cholesterol was distributed to a greater extent in this fraction. In lymph of the cholesterol‐low fat diet group, on the other hand, relatively more cholesterol was present in the smaller lipoproteins of Sf 12–400 . A comparison of the distribution of cholesterol estimated chemically with that of radioactivity following the ingestion of cholesterol‐4‐ 14 C suggested that the small lipoproteins of D > 1.019 were to a large extent derived by filtration from the serum and that some of the cholesterol of Sf 12–400 was derived from sources other than recently ingested cholesterol, while a high proportion of cholesterol of chylomicrons was derived from food.