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THE EFFECT OF PROSTAGLANDIN F 2 α UPON CORONARY VENOUS FLOW AND MYOCARDIAL METABOLISM
Author(s) -
Maxwell GM
Publication year - 1969
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1969.168
Subject(s) - coronary sinus , medicine , prostaglandin , blood flow , hemodynamics , fatty acid , cardiology , venous blood , metabolism , carbohydrate metabolism , cardiac output , endocrinology , chemistry , biochemistry
Summary General haemodynamics and coronary sinus flow (thermodilution flowmeter), and myocardial extraction of glucose, lactate, pyruvate and nonesterified fatty acid were measured before and after the injection of proslaglandin F 2 α in anaesthetized dogs. Systemic and pulmonary arterial pressures increased; cardiac output decreased transiently, coronary venous flow increased. Little change was found in myocardial O 2 and CO 2 metabolism. Cardiac efficiency decreased. Arterial lactate, pyruvate and non‐esterified fatty acid values increased; glucose was unchanged. Myocardial extraction values for these substrates did not change significandy. Some of the changes noted did not appear when stoichiometric amounts of prostaglandin F 2 α and prostaglandin E 1 were injected together.