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MACROPHAGE INTERLINKAGE REACTION INDUCED BY PHYTOHAEMAGGLUTININ AND BY TUBERCULIN
Author(s) -
Maclaurin BP
Publication year - 1969
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1969.10
Subject(s) - phytohaemagglutinin , cytoplasm , immunology , macrophage , intracellular , tuberculin , population , biology , chemistry , immune system , microbiology and biotechnology , medicine , pathology , tuberculosis , biochemistry , in vitro , environmental health
Summary. Phytohaemagglutinin is shown to produce marked changes in the appearance and behaviour of macropbages in monolayer tissue culture. Rapid induction of intercellular cytoplasmic bridging is described and the term Macrophage Interlinkage Reaction is proposed to designate this phenomenon. Similar interlinkage can be induced between sensitized macrophages by stimulation with tuberculin, but is not seen when unsensitized cells are used. The suggestion is made that cytoplasmic bridging could enable rapid dissemination of antigen throughout the lymph node macrophage population and thereby enhance the speed and intensity of the secondary immune response.