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FURTHER STUDIES REGARDING THE QUESTION OF CELLULAR IMMUNITY IN MOUSE TYPHOID
Author(s) -
Rowley D,
Auzins I,
Jenkin CR
Publication year - 1968
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1968.38
Subject(s) - immunity , salmonella , typhoid fever , biology , microbiology and biotechnology , salmonella enteritidis , population , macrophage , immunology , organism , antibody , virology , strain (injury) , immune system , medicine , bacteria , in vitro , genetics , environmental health , anatomy
Summary The immunity of mice to Salmonella typhimurium infections has been investigated, using killed and living vaccines of the specific organism and also an apparently unrelated rough strain of Salmonella enteritidis 11RX. It is concluded from the result of these experiments that treatment of mice, with living vaccines of both strains, that leads to immunity to S. typhimurium infection is dependent on an increased bactericidal activity of the macrophage population which requires specific antibody for its expression.