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IMMUNOLOGICAL RESPONSES IN RATS FOLLOWING ANTIGENIC STIMULATION OF PEYER'S PATCHES
Author(s) -
Cooper GN,
Turner Kaye
Publication year - 1968
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1968.35
Subject(s) - peyer's patch , lymphatic system , spleen , small intestine , antibody , antigen , microfold cell , lumen (anatomy) , stimulation , immunology , biology , peripheral blood , medicine , endocrinology
Summary The techniques of Peyer's patch infection and preparation of isolated intestinal loops in rats have been used in on attempt to determine whether coproantibody, formed in the local lymphoid tissues, passes directly from these sites to the intestinal lumen. Contrary to this belief, the results suggest that the bulk of antibody which accumulates in the intestine reaches there by way of the blood stream, irrespective of whether it is produced in local or peripheral tissues. The effects of secondary or tertiary injections of small doses of sheep red blood cells given at 3‐week intervals to rats initially injected by the Peyer's patch or intravenous routes have also been studied. While repeated intravenous injections resulted in primary‐type responses, greatly increased serum antibody titres were observed in animals challenged intravenously after a Peyer's patch injection. In the latter circumstances the greater secondary response was reflected by development of larger numbers of haemolytic plaque‐forming cells in the spleen but not in other lymphoid tissues.