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THE LOCAL ACTION OF AMMONIUM, CALCIUM AND MAGNESIUM ON ADRENOCORTICAL SECRETION
Author(s) -
BlairWest JR,
Coghlan JP,
Denton DA,
Goding JR,
Wintour Marelyn,
Wright HD
Publication year - 1968
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1968.31
Subject(s) - calcium , aldosterone , magnesium , endocrinology , medicine , chemistry , ammonium chloride , secretion , ammonium , ammonia , glucocorticoid , chloride , inorganic chemistry , biology , biochemistry , organic chemistry
Summary Solution of ammonium chloride, magnesium chloride and calcium chloride were infused locally into the adrenal arterial blood supply of conscious sheep with autotransplanted adrenal glands. At rates of infusion calculated to increase ammonia concentration by 1 mEq./l, or more. NH 4 Cl increased aldosterone secretion without a regular effect on glucocorticoid secretion. Increase of plasma magnesium concentration by 1–6 mEq./l. or plasma calcium by 2–10 mEq./l. did not affect aldosterone secretion.