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ANTIGEN LOCALIZATION AND THE IMMUNE RESPONSE AS A FUNCTION OF AGE
Author(s) -
Legge Josephine S,
Austin Caroline M
Publication year - 1968
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1968.29
Subject(s) - flagellin , white pulp , spleen , antigen , antibody , immune system , immunology , histology , biology , follicular phase , medicine , pathology , endocrinology , receptor
Summary The pattern of localization of 123 I‐polymerized flagellin prepared from SW1338 was studied in the spleens of young (3–4 month) and aged (18–27 month) C57B1 mice. Young animals invariably localized antigen in the primary and secondary follicles contained within the white pulp. Aged animals varied in their ability to localize antigen, the variation correlating with variable spleen histology. Improvement in follicular localization in aged mice was noted in the presence of specific active or passive antibody. Aged mice given a single intravenous injection of polymerized flagellin developed a level of serum anti‐H antibodies not detectably different from that of a group of young mice. On secondary challenge, however, antibody response of aged mice was markedly depressed.