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6‐MERCAPTOPURINE ADMINISTRATION TO NZB MICE
Author(s) -
Casey TP
Publication year - 1968
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1968.26
Subject(s) - mercaptopurine , medicine , immunology , autoimmune hemolytic anemia , drug , antibody , evans syndrome , drug administration , coombs test , pharmacology
Summary An intensive course of 6‐Mercaptopurine therapy in NZB mice immediately before the overt onset of their autoimmune haemolytic disorder did not delay or modify the subsequent development of antierythrocyte auto‐ antibody or of anaemia. Anaemic mice tolerated the drug poorly. They became more anaemic without lessening of strength of Coombs tests. It is suggested that the drug should be used with caution in anaemic patients with autoimmune disorders.