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THE IMMUNOGLOBULIN RESPONSE OF RATS TO AMPLICAECUM ROBERTSI INFESTATIONS
Author(s) -
Dobson C
Publication year - 1968
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1968.25
Subject(s) - antigenicity , titer , antibody , immunology , immunoglobulin m , antibody response , chemistry , biology , immunoglobulin g
Summary Rats infested with Amplicaecum robertsi responded by the formation of IgM and IgG antibodies and by showing Prausnitz‐Küstner activity. The IgM response was large and protracted and the antiboidy was heat‐ and mercapto‐ethanol‐labile. The production of IgG antibody started 2 days after IgM and was never very large reaching an early low peak titre. The theoretical implications of the IgM response are discussed in relation to the antigenicity of nematodes.