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EFFECT OF NEONATAL THYMECTOMY AND THIOTEPA ON THE SUSCEPTIBILITY OF MICE TO THE LETHAL EFFECTS OF POXVIRUSES
Author(s) -
Subrahmanyan TP
Publication year - 1968
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1968.21
Subject(s) - ectromelia virus , virology , cowpox virus , thiotepa , virus , ectromelia , biology , cowpox , orthopoxvirus , thymectomy , vaccinia , microbiology and biotechnology , immunology , chemotherapy , genetics , myasthenia gravis , gene , recombinant dna , cyclophosphamide
Summary Neonatal thymectomy or treatment with the cytotoxic drug Thiotepa increased the susceptibility of regular adult mice to attenuated ectromelia virus, probably because of their effects on the immune response. Neonatal thymectomy had no effect on the susceptibility to ectromelia virus of low pathogen mice or mice fed broad spectrum antibiotics, suggesting that enteric organisms play an important part in determining the resistance to ectromelia virus. The ability of adult mice to resist the lethal effects of subcutaneously injected cowpox virus was not affected by neonatal thymectotny or Thiotepa treatment. The treated mice surviving cowpox virus infection did not show hypersensitive footpad responses to ectromelia virus challenge, but they nevertheless resisted challenge.