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SERUM INSULIN AND GLUCAGON DURING THE GLUCOSE TOLERANCE TEST.
Author(s) -
Young JD,
Jenkinson IS
Publication year - 1968
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1968.177
Subject(s) - glucagon , radioimmunoassay , endocrinology , medicine , insulin , blood sugar , diabetes mellitus , glucose tolerance test , carbohydrate metabolism , blood sugar regulation , insulin resistance
Summary Using the radioimmunoassay technique, simultaneous measurements of serum insulin and serum glucagon levels at 10‐min. intervals or periods of 1 to 6 hr. have been made‐ on 15 normal subjects, 8 obese diabetics and 5 patients suffering from diabetes mellitus, while undergoing the oral glucose tolerance test. In addition, simultaneous blood sugar determinations were made. The general features of the observed damped oscillations in serum levels of sugar, insulin and glucagon are discussed in terms of a feedback loop of control acting between the physiological variables involved. The feedback loop is based on the known physiology of glucose metabolism.