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THE EFFECTS OF ALPHA‐ADRENERGIC RECEPTOR BLOCKADE AND SYMPATHETIC DENERVATION ON THE PRESSOR ACTION OF ANGIOTENSIN IN MAN
Author(s) -
Scroop GC,
Whelan RF
Publication year - 1968
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1968.163
Subject(s) - phentolamine , medicine , angiotensin ii , renin–angiotensin system , sympathetic nervous system , vasoconstriction , endocrinology , adrenergic , blood pressure , clonidine , blockade , denervation , receptor
Summary Intravenous phentolamine abolished the sympathetically‐mediated hand vasoconstriction which occurs during intravenous infusions of angiotensin in normal subjects. However, the blood pressure response was not significantly modified, indicating that the sympathetic stimulating action of angiotensin, in the doses and duration of exposure used, did not make a major contribution to the overall increase in peripheral resistance. This conclusion is supported by the observation of enhanced pressor responses to angiotensin in two patients with autonomic nervous system degeneration and in one patient with complete cervical cord transection. The failure of phentolamine to modify the pressor response to angiotensin indicates that with the doses used adrenal medullary release of catecholamines, which is known to occur in animals during angiotensin infusions, does not make a significant contribution to the pressor response in man.