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THE MEDIATION OF INCREASED VASCULAR PERMEABILITY IN INFLAMMATION
Author(s) -
Muller HK,
Salasoo I,
Wilhelm DL
Publication year - 1968
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1968.14
Subject(s) - vascular permeability , permeability (electromagnetism) , evans blue , histamine , chemistry , endocrinology , globulin , medicine , immunology , biology , biochemistry , membrane
Summary Rabbit serum contains a permeability factor which increases vascular permeability in the homologous species for periods up to 4 hr. Such prolonged permeability effects contrast markedly with those of other endogenous factors, which increase permeability for only about 10–20 min. When rabbit serum is fractionated in ethyl ether or ethanol systems, the permeability factor is mainly concentrated in preparations containing α‐ and β‐globulins. Tested in animals with circulating Evans′ blue, the permeability factor has an activity in 1‐hr. lesions that increases as much as 280‐fold in the ensuing 3 hr. The duration of increased permeability is best demonstrated by the injection of intravenous dye in animals already bearing lesions of varying ages. Tested by this technique, rabbit permeability factor induces a maximal increase of vascular permeability in 1½–2½ hr., normal low permeability being restored in 4 hr. On a weight basis relative to histamine, the most active preparations at this stage of the work have a permeability factor potency of 0·3 the dosage‐ response lines having a slope of 4·4–6·3.