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CONTROL OF FATTY ACID SYNTHESIS IN HOMOGENATE PREPARATIONS OF MOUSE HEPATOMA BW 7756
Author(s) -
Sabine John R,
Chaikoff IL
Publication year - 1967
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1967.53
Subject(s) - fatty acid synthesis , microsome , biochemistry , fatty acid , enzyme , activator (genetics) , cell , biology , chemistry , medicine , gene
Summary The malonyl‐CoA pathway for the incorporation of acetate into long‐chain fatty acids appears to be active in the mouse hepatoma BW 7756. The synthesis of fatty acids in the cell sap/microsome fraction of this tumour is inhibited by palmitate and palmityl CoA, and synthesis in the cell sap is stimulated by the addition of microsomes. These are factors that have been implicated in the “physiological” regulation of fatty acid synthesis in normal liver. It thus seems unlikely that in the tumour the enzymes of fatty acid synthesis have been appreciably altered, either during the neoplastic process or later. Therefore, some other hypothesis seems needed to explain the insensitivity of fatty acid synthesis in this hepatoma to dietary changes that can grossly affect synthesis in the liver, and we suggest this may he due to inability of the actual inhibitor(s) or activator(s) to enter the tumour cell.