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BLOOD BRADYKININ LEVELS IN THE HUMAN
Author(s) -
Zacest R,
Mashford ML
Publication year - 1967
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1967.5
Subject(s) - bradykinin , human blood , hemodynamics , medicine , endocrinology , anesthesia , chemistry , physiology , receptor
Summary A method for the assay of blood levels of bradykinin is described with which it is possible to measure levels in the blood of all normal subjects so far examined. The average bradykinin level in brachial arterial blood in 18 subjects was 0·25 ng./ml. (standard deviation 0·23 ng./ml.). These levels are lower than others reported. The average recovery of internal standard of 97% suggests that these figures are not low due to losses in the procedure. The method is sufficiently sensitive to detect changes in blood levels of bradykinin during the infusion of small doses of synthetic bradykinin which produced only moderate haemodynamic effects.