Premium
EFFECT OF ANAEMIA ON OXYGEN TRANSPORT IN SHEEP WITH DIFFERENT HAEMOGLOBIN TYPES
Author(s) -
Dawson Terence J,
Evans JV
Publication year - 1967
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1967.42
Subject(s) - oxygen transport , oxygen , significant difference , medicine , zoology , biology , chemistry , endocrinology , organic chemistry
Summary The effect of chronic anaemia on oxygen transport in sheep with genetically different haemoglobins was studied. Measurements were made before and after the haematocrits of the two types of sheep had been reduced by blood removal to the same low anaemic level. The results showed that sheep with haemoglobin‐A (the haemoglobin with higher oxygen affinity) had a significantly greater cardiac output than sheep with haemoglobin‐B. Most of the difference in cardiac output could be attributed to the poorer ability of the blood of sheep with Hb‐A to liberate oxygen in the tissue capillaries, although there was some difference in oxygen consumption between the two groups. The results were considered with respect to the more complex chronic anaemias which occur under field conditions.