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THE EFFECT OF CYTOTOXIC DRUGS ON SERUM ALBUMIN IN THE RAT
Author(s) -
Vincent PC,
Reeve TS,
Brittle Nea,
Nicholls Annette,
Richards Margaret
Publication year - 1967
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1967.41
Subject(s) - albumin , malabsorption , medicine , endocrinology , serum albumin , globulin , excretion , blood proteins , cytotoxic t cell , chemistry , protein metabolism , metabolism , biochemistry , in vitro
Summary Rats treated with single large doses of cyclophosphamide developed significant and selective hypoalbuminaemia, leading to a decrease in total serum protein concentration despite normal globulin levels. The depression in serum albumin coincided with the time of greatest weight loss, but starvation causing similar weight loss did not cause a fall in serum albumin. Increased urinary excretion of protein was observed in treated rats, but malabsorption, gastro‐intestinal protein loss and disturbed albumin metabolism may also have contributed to the hypoalbuminaemia. Three other cytotoxic drugs were studied, but none showed a similarly specific effect on serum albumin.