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THE STEADY STATE IN CELLULAR IMMUNITY
Author(s) -
Gray DF,
Cheers Christina
Publication year - 1967
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1967.40
Subject(s) - immunity , tuberculosis , immunology , steady state (chemistry) , microbiology and biotechnology , bordetella pertussis , biology , medicine , chemistry , immune system , bacteria , pathology , genetics
Summary Murine pertussis infection showed the phenomenon of immunological complaisance previously observed in murine pulmonary tuberculosis. Following a brief period of about bactericidal activity at the onset of immunity, a steady State ensured for about one month. During this time artificial disturbances in the host‐bacterial equilibrium were rapidly corrected. The control exercised was both positive and sensitive Unlike murine tuberculosis, tuberculosis, however, the pertussis complaisant state tended to be replaced by further bactericidal activity leading to complete recovery. The mechanisms o f the complaisant state in murine pertussis and of the subsequent decline phase are being examined.