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EOSINOPHILIA IN RATS INFECTED WITH AMPLICAECUM ROBERTSI
Author(s) -
Archer GT,
Barker Angela,
Air Gillian,
McGovern VJ
Publication year - 1966
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1966.5
Subject(s) - histamine , eosinophilia , medicine , endocrinology , stomach , significant difference , biology , chemistry
Summary Infective ova of the ascaroid parasite Amplicaecum robertsi were shown to cause pronounced eosinophilia following injection into the stomach of rats. Eosinophila developed 7 days after injection of the eggs and reached maximum values at approximately 18 days after infection, when there was a 8‐fold increase above control values. The level of eosinophils in the blood gradually decreased from the maximum values, but significant eoinophilia was still present at 40 days. A significant decrease was found in the level of 11‐hydroxycorticoids in the plasma of Amplicaecum‐infected rats compared with normal animals. The rate of clearance of colloidal carbon from the bloodstream was found to be greater in Amplicaecum‐treated animals than in normal rats. No significant difference was demonstrated in plasma histamine levels in normal and Amplicaecuminfected animals following an injection of the histamine release agent, dextran.