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REFLEX EFFECTS OF CAROTID BODY CHEMORECEPTOR STIMULATION ON THE HEART RATE OF THE RABBIT
Author(s) -
Scott Mary J
Publication year - 1966
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1966.37
Subject(s) - chemoreceptor , carotid body , stimulation , efferent , bradycardia , hyperventilation , reflex , heart rate , perfusion , medicine , reflex bradycardia , anesthesia , anatomy , blood pressure , afferent , receptor
Summary The isolated carotid bifurcation regions of the rabbit were perfused with blood. Stimulation of the chemoreceptors in the carotid bodies was achieved by perfusion with hypoxic blood from a donor rabbit. Under conditions of controlled ventilation, chemoreceptor stimulation caused a slowing of the heart. This response was considerably modified by hyperventilation, either occurring spontaneously with the chemoreceptor excitation or induced artificially. The responses occurred whether the aortic depressor nerves were intact or not. The bradycardia of chemoreceptor origin was mediated both by vagal efferent pathways and by sympathetic fibres to the heart.