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SOME ASPECTS OF POST‐EXERCISE HYPERAEMIA IN MAN
Author(s) -
Brandon KW,
Cooper CJ,
Fewings JD,
Walsh JA,
Whelan RF
Publication year - 1966
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1966.36
Subject(s) - hyperaemia , acetylcholine , forearm , neostigmine , atropine , vasodilation , brachial artery , medicine , venous blood , endocrinology , anesthesia , blood flow , cardiology , anatomy , blood pressure
Summary A technique is described for the assay of vasoactive substances in venous blood draining from the forearm muscles of one arm by the injection of a sample of the venous blood into the brachial artery of the opposite arm and the measurement of blood flow through that forearm. Using this technique, no vasoactive substance was detected in venous blood from exercising muscle. An altered response of the superfused guinea‐pig ileum to venous blood draining from human skeletal muscle at the end of a 4‐minute period of rhythmic exercise was observed in 8 of 11 experiments. The precise identity of the substance responsible was not determined, but the nature of its effect on the guinea‐pig ileum was more suggestive of acetylcholine than of histamine. The role of acetylcholine in the post‐exercise hyperaemia of the human forearm was examined by determining the effect of intra‐arterial infusions of the acetylcholine‐blocking agents atropine and hyoscine and the anticholinesterase neostigmine. Intra‐arterial infusions of atropine and hyoscine did not alter the post‐exercise hyperaemia and it is concluded that acetylcholine normally plays no part in the production of the hyperaemia. Post‐exercise hyperaemia was increased by the use of neostigmine, suggesting that, in this circumstance, acetylcholine liberated from the motor end‐plates causes vasodilatation which is additive to the post‐exercise hyperaemia.