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ACUTE LIVER INJURY DUE TO ALBITOCIN
Author(s) -
Kerr JFR,
Pound AW
Publication year - 1966
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1966.20
Subject(s) - necrosis , cytoplasm , acid phosphatase , pathology , lesion , chemistry , infiltration (hvac) , liver injury , biology , biochemistry , medicine , endocrinology , enzyme , physics , thermodynamics
Summary Albitocin, a triterpenoid glycoside extracted from the bark of Albizia gummifera , produced liver damage when injected into mice and rats. The milder forms of the lesion comprised nuclear enlargement and cytoplasmic fatty infiltration which was maximal in the outer parts of the lobules. In severely affected animals cells in the peripheral and intermediate zones underwent necrosis, and there was often marked dilatation of sinusoids. Periodic acid Schiff (P.A.S.)‐positive, spherical bodies were common in the cytoplasm of the injured cells. These were rich in acid phosphatase and esterase, and correspond to the large lysosomes described in other forms of liver cell injury. Promethazine hydrochloride, in the dose used, afforded no protection from death or liver necrosis.