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FATTY ACIDS AND IN VITRO PLATELET AGGREGATION
Author(s) -
Ardlie NG,
Kinlough Raelene L,
Glew G,
Schwartz CJ
Publication year - 1966
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1966.12
Subject(s) - stearic acid , chemistry , platelet , platelet aggregation , adenosine diphosphate , in vitro , palmitic acid , linoleic acid , biochemistry , fatty acid , oleic acid , adenosine triphosphate , food science , medicine , organic chemistry
Summary Platelet aggregation was assessed photometrically. Stearic acid at a final concentration of 0·83 × 10 −4 M was the only fatty acid found to enhance the clumping activity produced by the combined effect of adrenaline and adenosine triphosphate. None of the five fatty acids tested, palmitic, stearic, oleic, linoleic or linolenic, produced any effect when added to platelet‐rich plasma alone nor did they effect the platelet aggregation induced by adenosine diphosphate. The significance of this property of stearic acid awaits further experiment.