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THE EFFECT OF COLCHICINE ON THE ABSORPTION OF WATER AND ELECTROLYTES BY RAT JEJUNUM
Author(s) -
Goulston Kerry J,
Skyring Alan
Publication year - 1966
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1966.10
Subject(s) - colchicine , jejunum , potassium , in vivo , sodium , perfusion , absorption (acoustics) , medicine , chemistry , absorption of water , endocrinology , gastroenterology , biology , materials science , botany , microbiology and biotechnology , organic chemistry , composite material
Summary Colchicine given parenterally to rats in a dose of 80 μg./100 g. produced atrophic changes in the jejunal mucosa which differed in many respects from those seen in human idiopathic steatorrhoea. Perfusion studies performed in vivo on the third day showed a significant reduction in the rates of absorption of water, sodium and potassium. Both bi‐directional fluxes of sodium were greatly reduced.