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IgG AND IgM ANTIBODIES IN FOWL SERUM
Author(s) -
Szenberg A,
Lind Patricia,
Clarke K
Publication year - 1965
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1965.79
Subject(s) - antibody , fowl , bovine serum albumin , titer , antigen , immunology , biology , paleontology
Antibody production in mammals in response to a variety of antigens has been extensively investigated. An early appearance of IgM antibodies was usually followed by IgG antibodies (Bauer, Mathies and Stavitsky, 1963). The activity of IgM antibodies was destroyed by treatment with 0·1 M 2‐mercaptoethanol (ME) (Deutsch and Morton, 1957), whilst the titre of IgG antibodies was not diminished. In the fowl a similar pattern of antibody response has been described (Uhr, Finkelstein and Franklin. 1962; Benedict. Brown and Hirsch, 1963; Drecsman, Larson, Pinckard, Groydon and Benedict, 1965). Rosenquist and Gilden (1963), however, found no IgM antibodies in fowl serum in response to bovine serum albumin (BSA) and the antibody titre in the IgG fraction was destroyed by incubation with ME. The results presented in this communication are concerned with (1) the susceptibility of fowl IgG antibodies to ME treatment; and (2) the production of IgM antibodies by the fowl.