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HYPNOTIC‐ANALEPTIC INTERACTION AT DIFFERENT NEURAL LEVELS IN CATS AND RABBITS
Author(s) -
Laycock Glenda M,
Shulman A,
Wright RD
Publication year - 1965
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1965.62
Subject(s) - analeptic , hypnotic , cats , anesthesia , pentobarbital , central nervous system , chemistry , pharmacology , neuroscience , medicine , psychology
Summary The antagonism of the analeptics bemegride, β‐spirocyclopentane‐gluttarimide, pentylenetetrazol and picrotixin to the hypnotic action of pentobarbitone sodium has been measured in intact and decerebrate rabbits and decerebrate and decapitate cats. Hypnotic‐analeptic interaction is not confined to localized segments of the central nervous system, and in all preparations the analeptic activities of the four drugs are in the same rank order; analeptic activity is least in the decapitate cat preparation. The findings are consistent with actions of pentobarbitone sodium and the four anuleptics at common sites in the central nervous system.