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STONEFISH VENOM: SOME BIOCHEMICAL AND CHEMICAL OBSERVATIONS
Author(s) -
Austin L,
Gillis RG,
Youatt G
Publication year - 1965
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1965.6
Subject(s) - venom , hyaluronidase , sephadex , chemistry , chromatography , enzyme , carboxymethyl cellulose , biochemistry , ultracentrifuge , sodium , organic chemistry
Summary Stonefish venom has been fractionated on carboxymethyl cellulose and Sephadex columns; of the fractions obtained only one was toxic to rats. The active fraction contained a relatively high proportion of aromatic amino acids. Whole venom was examined for enzyme activity and enzyme inhibition; the only significant activity found was that of hyaluronidase. The venom also caused a marked increase in capillary permeability. Ultracentrifuge measurements suggest that the toxic material has a molecular weight of the order of 150,000.