STONEFISH VENOM: SOME BIOCHEMICAL AND CHEMICAL OBSERVATIONS | Zendy

Austin L | Zendy; Gillis RG | Zendy; Youatt G | Zendy

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STONEFISH VENOM: SOME BIOCHEMICAL AND CHEMICAL OBSERVATIONS

Author(s) -

Austin L,

Gillis RG,

Youatt G

Publication year - 1965

Publication title -

australian journal of experimental biology and medical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.999

H-Index - 104

eISSN - 1440-1711

pISSN - 0004-945X

DOI - 10.1038/icb.1965.6

Subject(s) - venom , hyaluronidase , sephadex , chemistry , chromatography , enzyme , carboxymethyl cellulose , biochemistry , ultracentrifuge , sodium , organic chemistry

Summary Stonefish venom has been fractionated on carboxymethyl cellulose and Sephadex columns; of the fractions obtained only one was toxic to rats. The active fraction contained a relatively high proportion of aromatic amino acids. Whole venom was examined for enzyme activity and enzyme inhibition; the only significant activity found was that of hyaluronidase. The venom also caused a marked increase in capillary permeability. Ultracentrifuge measurements suggest that the toxic material has a molecular weight of the order of 150,000.

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