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EFFECTS OF INTRAVITREOUS INJECTION OF DRUGS ON THE CHOLINESTERASE OF THE RETINA
Author(s) -
Rose SAM,
Glow Peter H
Publication year - 1965
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1965.58
Subject(s) - retina , cholinesterase , acetylcholine , pharmacology , ophthalmology , chemistry , medicine , neuroscience , biology
Summary The cholinesterase activity of excised retinas was measured after intravitreous, intramuscular, and intracarotid injection of various combinations of diisopropylfluorophosphate, octamethylpyrophosphoramide, 1,3 bis (4‐hydroxyi‐minoethylpyridinium) propane dibromide (C434) and acetylcholine. Cholinesterase activity of the retina could be manipulated independently in each eye, without systemic effects, by intravitreous injection of drugs even if these drugs would not have penetrated from the blood to the retina. The advantages of using retina for biochemical and pharmacological studies on neural tissues are discussed.