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LOCALIZATION OF PARTICULATE CARBON IN METAPHYSEAL VESSELS OF GROWING RATS
Author(s) -
Ham Kathryn N,
Hurley JV,
Ryan GB,
Storey E
Publication year - 1965
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1965.47
Subject(s) - metaphysis , endothelium , anatomy , basement membrane , pathology , chemistry , biology , medicine , endocrinology
Summary Intravenously injected carbon particles localize selectively adjacent to blood vessels in the metaphysis of long bones of young rats. Deposition is greatest in rapidly growing animals, and decreases as the growth rate slows in older animals. Similar deposition cannot be detected in relation to growing vessels in either granulation tissue or recent tumour implants. Electron microscopic examination shows that the growing ends of metaphyseal blood vessels consist only of attenuated endothelium containing numerous wide gaps. At deeper levels in the metaphysis the vascular wall is much thicker, and resembles actively growing vessels seen in other tissues. Occasional gaps in the endothelium occur here, and neither a basement membrane nor peri‐endothelial cell layer is present. It appears that carbon deposition in the metaphysis is due to the peculiar structure of its small blood vessels, and does not indicate a temporary change associated with an increase in vascular permeability to protein as it does in most other tissues.