Premium
SPLEEN GRAFT MAST CELL POPULATION CHANGES FOLLOWING SPLENECTOMY OF THE HOST
Author(s) -
Metcalf Donald
Publication year - 1965
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1965.39
Subject(s) - spleen , splenectomy , mast cell , population , cell , kidney , medicine , immunology , andrology , biology , pathology , environmental health , genetics
Summary One‐day‐old C57B1 spleens grafted to splenectomised C57B1 and (AKR × C57B1)F 1 recipients grew to a three times larger size, but contained fifteen to twenty times fewer mast cells than comparable grafts in sham operated recipients. Splenectomy of mice bearing established Spleen grafts led to a similar increase in graft size and fall in mast cell content. These effects of splnectomy were observed with both subcutaneous und kidney sub‐capsular spleen grafs. Confirmatory results were obtained with AKR and C3H spleen grafts in isologous and F 1 hybrid splenectomised and sham operated recipients. Treatment of splenectomised mice with spleen extracts or spleen tissue in dif fusion chambers did not change the number of spleen graft mast cells. Splenec‐tomy had no effect on the mast cell content of other host tissues, or on the mast cell content of thymus grafts. Splenectomy before pregnancy had no effect on mast cell development in the fix‐till spleen.