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CORTISONE ACETATE TREATMENT OF HAEMOLYTIC ANAEMIA IN NZB MICE
Author(s) -
Giltinan Pamela J,
Holmes Margaret C,
Burnet FM
Publication year - 1965
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1965.37
Subject(s) - cortisone , cortisone acetate , coombs test , reticulocyte , medicine , incidence (geometry) , endocrinology , immunology , chemistry , antibody , biochemistry , physics , messenger rna , optics , gene
Summary The effects of treatment of haemolytic anaemia in NZB mice with cortisone acetate were examined. A dosage of 2 mg./mtmsc/week, caused a reversal of the Coombs test in Coombs positive mice ami prevented the Coombs conversion in younger mice for as long as treatment was continued. The reticulocyte levels, which in control mice are grossly elevated, Were reduced to normal limits, but the haemoglobin and haematocrit levels were no different in treated mice from those in controls. This was ascribed to a probable iron deficiency anaemia associated with repeated experimental bleeding. There was a high incidence of infections in treated mice, and the mortality was higher than in the controls. For this reason, it was not possible to decide whether cortisone therapy decreased the incidence of renal lisions in the NZB mice.