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IMMUNOCYTOCHEMICAL LOCALIZATION OF A 19S γ1 MACROGLOBULIN COLD HAEMAGGLUTININ
Author(s) -
Curtain CC,
Baumgarten A
Publication year - 1965
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1965.12
Subject(s) - macroglobulin , antibody , bone marrow , lymphoma , globulin , plasmacytoma , microbiology and biotechnology , chemistry , biology , pathology , immunology , medicine , multiple myeloma
Summary A γ1 macroglobulin with cold haemagglutinating activity of the anti‐I type was localised by the fluorescent antibody technique in the bone marrow plasma cells and their precursors in a patient suffering from lymphoma. No localization occurred in the “naked” lymphocytes whose presence in the marrow gave rise to a diagnosis of lymphoma. The plasma cells containing the macroglobulin appeared to be morphologically identical to those containing normal 7S γ 2 ‐globulin, and in no case was the presence of both proteins observed in the same cell.