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PATHOLOGICAL CHANGES FOLLOWING EXPERIMENTAL OBSTRUCTION OF THE COMMON BILE DUCT, HEPATIC BILE DUCT AND HEPATIC ARTERY IN THE SHEEP AND THEIR RELATION TO FACIAL ECZEMA
Author(s) -
Leaver DD,
Christie GS
Publication year - 1965
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1965.1
Subject(s) - ligation , bile duct , medicine , pathological , fibrous capsule of glisson , artery , common bile duct , common hepatic duct , gastroenterology , pathology , anatomy
Summary Pathological changes in the sheep following ligation of the hepatic bile duct, combined ligation of both the hepatic bile duct and the branch of the hepatic artery to the ventral lobe, ligation of the common bile duct and ligation of the hepatic artery to the ventral lobe, are described and discussed. It was demonstrated that a combination of obstruction of the biliary drainage and a considerable decrease of the blood How was required to produce the maximum degree of bile ductule proliferation and parenchymal atrophy seen in the chronic stage of facial eczema in the sheep. Obstruction of the common bile duct did not reproduce the liver changes of facial eczema. Although evidence is cited in the sheep, which suggests that some degree of interference with blood supply followed ligalion of the hepatic duct only, the lesion produced was not comparable in degree to that of facial eczema.