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MACROPHAGE PROLIFERATION IN RELATION TO ACQUIRED CELLULAR RESISTANCE
Author(s) -
Khoo KK,
Mackaness GB
Publication year - 1964
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1964.67
Subject(s) - listeria monocytogenes , macrophage , spleen , biology , microbiology and biotechnology , immunology , listeria , population , antigen , bacteria , in vitro , medicine , genetics , environmental health
Summary The proliferative activity of peritoneal macrophages has been studied in mice systemically infected with L. monocytogenes and Br. abortus . A gross difference was found in the time‐course of infections caused by these organisms, but in each of them the percentage of DNA synthesising cells rose progressively to a peak on the 3rd day after the bacterial population in the spleen had reached a maximum. During a secondary Listeria infection the cellular response occurred sooner and was more intense. The findings are consistent with the view that the intense proliferation of macrophages associated with these infections is due to the action of bacterial antigens on immunologically sensitised cells.