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ENHANCEMENT OF THE VIRULENCE OF ATTENUATD ECTROMELIA VIRUS IN MICE MAINTAINED IN A COLD ENVIRONMENT
Author(s) -
Roberts John A
Publication year - 1964
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1964.63
Subject(s) - ectromelia virus , virus , ectromelia , biology , antibody , virology , strain (injury) , virulence , microbiology and biotechnology , immunology , anatomy , biochemistry , gene , vaccinia , recombinant dna
Summary An attenuated strain of ectromelia virus was at least 100 times more lethal for mice kept in a 2° environment, than it was for mice kept at 20°. Studio of the rates of virus growth in different organs indicated that a virus‐induced host factor, which retarded growth of virus in mice kept in a 20° environment, was deficient in mice kept in the 2° environment. Comparisons of the time of initiation of antibody production, the persistence of antibodies, and the ability of reticulo‐endothelial cells to dispose of virus‐antibody complexes, revealed no differences between groups of mice kept in each environment. The dependence of mice in a low temperature environment upon an increased metabolic rate rendered them more susceptible to liver damage.