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THE FATE OF Cr 51 LABELLED EHRLICH ASCITES TUMOUR CELLS
Author(s) -
Vincent PC,
Nicholls Annette
Publication year - 1964
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1964.53
Subject(s) - ascites , in vivo , spleen , excretion , in vitro , distribution (mathematics) , isotope , chemistry , intraperitoneal injection , ehrlich ascites , medicine , endocrinology , pathology , biology , tumor cells , biochemistry , cancer research , mathematical analysis , physics , microbiology and biotechnology , mathematics , quantum mechanics
Summary Elution of Na 2 Cr 51 O 4 after binding to Ehrlich ascites tumour cells is considerable, both in vitro and in vivo . The distribution and excretion of intravenously injected free Na 2 Cr 51 O 4 have been determined and with these data it has been estimated that approximately 64 per cent of isotope associated with tumour cells is lost in the first 24 hours after their intravenous injection into mice. Most (but not all) of the activity in the liver and spleen, and all of the activity in the kidneys after such an injection is due to the distribution of eluted isotope. However, a significant excess of radioactivity in the lungs of female mice when compared with male mice within one minute of injection of labelled cells is consistent with previous reports of greater metastatic tumour growth in female mice. Evidence is presented to show that clution of isotope is not responsible for this difference.