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THE DEVELOPMENT OF FIXED RABIES VIRUS IN MOUSE BRAIN
Author(s) -
Johnson Richard T,
Mercer EH
Publication year - 1964
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1964.42
Subject(s) - acridine orange , rabies virus , rabies , virology , virus , staining , cytoplasm , biology , virus strain , strain (injury) , rna , microbiology and biotechnology , anatomy , biochemistry , genetics , gene
Summary The development of fixed rabies virus in the cerebellar Purkinje cells of mice has been studied by immunofluorescent, cytochemical and electron microscopical methods. The virus, as judged by all methods, appears to devolop in the cytoplasm without any demonstrable nuclear involvement. The staining reaction with acridine orange suggests that rabies is an RNA virus. The morphology of the particles of the fixed strain used in these experiments differs from the street strain described by Matsumoto (1963) in being less often elongated and unbranched.