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EFFECTS OF SIMPLE LIPIDS ON THE PHAGOCYTIC PROPERTIES OF PERITONEAL MACROPHAGES
Author(s) -
Cooper GN,
Houston Barbara
Publication year - 1964
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1964.40
Subject(s) - triolein , ingestion , intracellular , in vitro , microbiology and biotechnology , biology , population , cell , phagocytosis , chemistry , biochemistry , medicine , environmental health , lipase , enzyme
Summary Mouse peritoneal cells which have ingested large numbers of Esdierichia coli in vitro are later incapable of ingesting small numbers of a second bacterial species ( Paracolobactrum ). If the cell populations which have been exposed to E. coli are treated with small concentrations of triolein, ingestion and intracellular killing of the second species occur. Using microscopic techniques, evidence has been obtained to suggest that the enhancement of phagocytic activity in cell populations by triolein is related to an increase in the number of functionally active cells rather than to an increase in the ingestive capacity of phagocytic cells initially present in the population.