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IMMUNOLOGICAL REACTIONS PRODUCED BY THE LOCAL INJECTION OF ADULT FOWL LEUCOCYTES IN CHICKENS
Author(s) -
Warner NL
Publication year - 1964
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1964.39
Subject(s) - fowl , wattle (construction) , infiltration (hvac) , antigen , lesion , peripheral blood , intradermal injection , pathology , immunology , homologous chromosome , biology , medicine , paleontology , biochemistry , physics , archaeology , gene , history , thermodynamics
Summary The intradermal injection of adult fowl blood leucocytes into the wattle of homologous chickens has been shown to produce a readily detectable reaction. The intensity can be followed by daily measurements of wattle thickness, the maximum being reached in about 4–5 days, and regressing by 10–12 days. Histologically, there is a large inflammatory exudate with prominent perivascular lymphocytic infiltration. The reaction is initiated by the injected cells only when a foreign antigen is present in the recipient. Preimmunisation of the recipient to the donor results in a profound suppression of the response. Donor immunisation does not increase lesion intensity; instead it also seems to cause some reduction. Blood leucocytes from hormonally bursectomised chickens were also shown to be fully competent by this criterion of immunological reactivity.